Justice O'Regan is a former judge of the South African Constitutional Court (1994 - 2016), an emeritus Professor in the Faculty of Law at the University of Oxford, an honorary professor at the University of Cape Town and a visiting professor at the London School of Economics and Political Science. She served as the inaugural Director of the Bonavero Institute of Human Rights at the University of Oxford from 2016 to 2025. Justice O’Regan has also served as an ad hoc judge of the Supreme Court of Namibia (from 2010 - 2016), Chairperson of the Khayelitsha Commission of Inquiry into allegations of police inefficiency (2012 – 2014), and as a member of the advisory bodies of many NGOs working in the fields of democracy, the rule of law, human rights and equality. Justice O’Regan became a Trustee of the MRF in 2019.